How Did Primordial Cells Evolve?
A study published by Cell Press February 28th in the journal Cell reveals how bacteria in this L-form state divide and proliferate, shedding light on how the earliest forms of cellular life may have replicated.
"The main surprise for me was how simple the mechanism was. It doesn't require any sophisticated protein-based machinery," says senior study author Jeff Errington of Newcastle University. "This makes it plausible as an explanation for how very primitive cells could have proliferated in the very early days of evolution."
The cell wall is a layered structure surrounding cells that protects them and maintains their shape. It is present in all known major bacterial lineages, and it was also probably present in the last common ancestor of bacteria. This structure is so important that it is targeted by antibiotics, and many bacteria responsible for infectious diseases can switch to the L-form state to resist antibiotics.
Addressing this question in the new study, Errington and his team identified two genetic changes required for L-form growth in bacteria. One of these mutations was necessary for the increased production of fatty acids in the cell membrane, which would be expected to increase the cell's surface area relative to its volume. Indeed, the researchers found that by artificially increasing cell surface area, they could induce L-form-like shape changes and cell division. The findings suggest that a simple biophysical change—an imbalance between surface area and volume—underlies L-form cell division.
"Our study paves the way for understanding how L-form bacteria cause disease and resist antibiotics," Errington says. "It also offers a model system for future experiments aimed at exploring the possible replication mechanisms of primitive cells that could have existed before the explosion of bacterial life on the planet nearly four billion years ago."